John J.P. Kastelein, M.D., Ph.D., FESC

Professor of Medicine, University of Amsterdam

Dr. John Kastelein is Professor of Medicine and Chairman of the Department of Vascular Medicine at the Academic Medical Center (AMC) of the University of Amsterdam, where he holds the Strategic Chair of Genetics of Cardiovascular Disease. Dr. Kastelein is a recognized world leader in studies focused on the significance of lipoprotein metabolism in the development of atherosclerotic vascular disease. Dr. Kastelein's current research interests focus on the etiology, diagnosis, prevention, and treatment of hypertriglyceridemia, hypercholesterolemia, and low HDL cholesterol, all conditions associated with atherosclerosis and cardiovascular disease. He has published more than 850 research papers in peer-reviewed journals, including Nature Genetics, Lancet, New England Journal of Medicine, JAMA, and Circulation. His Hirsch index is 114 as of March 2018; and his total citations are approaching more than 60,000.

Dr. Kastelein founded the Lipid Research Clinic at the Academic Medical Centre in Amsterdam in 1989, which is currently serving as a tertiary referral center for over 5000 patients each year and has become part of the Department of Vascular Medicine. Dr. Kastelein was President of the Dutch Atherosclerosis Society (DAS) and chairs the National Scientific Committee on Familial Hypercholesterolemia (EHC). He also is a member of the Royal Dutch Society for Medicine & Physics, the Council for Basic Science of the American Heart Association and the European Atherosclerosis Society, and a Fellow of the European Society of Cardiology. He also is a board member of the International Task Force for CHD Prevention and was recently appointed to the Executive Board of the International Atherosclerosis Society (IAS). In addition to the scientific programs aimed at the etiology of atherogenesis, Dr. Kastelein also served on a number of executive and steering committees of large cardiovascular intervention studies, including the SPIRE, ORION, GLAGOV, REALIZE, IDEAL, TNT, CAPTIVATE, ENHANCE, ILLUMINATE, JUPITER, RADIANCE and numerous others of which TNT (2005), RADIANCE 1 (2007), ENHANCE (2008), JUPITER (2008), SPIRE and ORION (2017) are published in the New England Journal of Medicine, IDEAL (2006) and GLAGOV (2017) in JAMA and RADIANCE 2 (2007) and REALIZE (2016) in Lancet.

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