Contact Information

ADDRESS

Matinas BioPharma Holdings, Inc.
1545 Route 206 South
Suite 302
Bedminster, NJ 07921

Matinas BioPharma Nanotechnologies
Center of Excellence, Building L-3
1025 Route 202/206, 3rd Floor
Bridgewater, NJ 08807

PHONE

908-484-8805

Investor Relations Contacts

Investor Relations

Peter Vozzo
T: (443) 213-0505
Peter.vozzo@westwicke.com

Transfer Agent

VStock Transfer, LLC
18 Lafayette Place
Woodmere, NY 11598
T: (212) 828-8436
F: (646) 536-3179
info@vstocktransfer.com

Join a team of driven scientific minds, innovation leaders and problem solvers.

Our people are the core of our innovative success across expanding scientific fields. They are passionate about developing disruptive medicines that can improve the lives of patients. We consistently seek individuals with that same drive and ability to solve complex issues in the biopharmaceutical space.

Matinas provides a broad range of opportunities for personal and professional growth in an intellectually challenging work environment. We are proud to say we are an equal opportunity employer offering competitive compensation and excellent employee benefits.


Opportunities

AD Scientist Level III

Basic Function

The Scientist Level III is a seasoned AD chemist that performs development, optimization, transfer and validation of analytical methods for products and raw materials.  When required, the scientist supports testing of raw materials, in-process, finished product and stability samples in support of clinical studies, stability and product development. Tests include assay, chromatographic purity, content uniformity, particle size distribution, density, water determination by KF and TOC according to in-house methods and USP monographs.

Specific Job Responsibilities

  • Performs development, optimization, transfer and validation of methods for products and raw materials.
  • Troubleshoots methods to determine root causes of issues and verifies methods for release to the lab.
  • Prepares analytical methods, protocols, reports and standard operating procedures, as required.
  • Performs testing of raw materials, in-process, finished product and stability samples including HPLC assay, chromatographic purity, content uniformity, particle size distribution, density, water determination by KF and TOC according to in-house methods and USP monographs in support of clinical studies and biopharma drug product development.
  • Maintains accurate lab notebooks, completes all related analytical reports, writes summaries and keeps proper documentation in compliance with SOP’s. Ensures notebooks are reviewed in a timely manner in accordance with SOP requirements.
  • Assists in maintaining and calibrating laboratory equipment (e.g. HPLC, GC).
  • Maintains the laboratory and work areas as per good housekeeping practices and in compliance with EHS.

Required Skills and Competencies

  • Prior experience with the optimization and validation of analytical test methods.
  • Working knowledge of laboratory instrumentation as referred to in job responsibilities and associated software where applicable. Extensive experience with Empower is required.
  • Ability to work on multiple method (HPLC, GC, PSD) projects of a complex nature simultaneously.
  • Experience investigating complex test failures and determining root causes.
  • Ability to carry out and complete necessary computations and present / interpret data.
  • Working knowledge of USP, ICH and FDA guidelines in a GMP regulated lab environment.
  • Possesses and demonstrates a wide degree of creativity and problem-solving skills. 
  • Excellent communications skills with demonstrated ability to communicate clearly in English in both written and spoken form.

Education and Experience

  • BS degree in chemistry or related discipline. MS degree preferred.
  • 5 plus years relevant experience with BS degree. 3 plus years with MS. Pharmaceutical lab experience required, with biopharma lab experience preferred.
  • Able to perform laboratory function associated with position and required in a research lab.

Physical Qualifications

  • Standing to perform bench tests, bending, lifting up to 40 lbs, and ability to wear all required safety equipment such as safety glasses, mask, gloves, lab coat as work and environment require.

To apply please email your resume to Careers@MatinasBioPharma.com

Director of Drug Product Development

Director of Drug Product Development to lead drug product development with a focus on lipid based formulations. The individual will play an essential role in cross-functional teams and will be responsible for driving activities related to drug product process & manufacturing development. The primary responsibility will be for a mid/late-stage product development and NDA preparation. The responsibilities include process development and optimization of the technical operations associated with lipid based suspension and oral drug products and process characterization. This position will report to the Vice President, Manufacturing & Supply Chain.

Responsibilities

  • Ensures all drug process development and manufacturing development activities for drug products are aligned with Matinas BioPharma's project goals and timelines.
  • Design and execute various studies to support process selection and manufacturing unit operations including stability and excipient selection, freeze/thaw, mixing, filtration, bottle filling and spray drying,
  • Lead/manage DOE and risk assessments to finalize the DP formulation and manufacturing processes.
  • Works collaboratively with internal stakeholder functions such as Clinical Manufacturing, Project Management, Clinical, and Regulatory to meet program goals. Coordinates seamlessly with colleagues overseeing formulation and analytical development activities.
  • Oversee activities related to drug product/clinical supply at external vendors/CMO’s, including oversight of scale up, process optimization & prototyping.
  • Reviews all drug product related technical documents, including process research & development reports, master batch record documentation, campaign reports, and validation protocols & reports.
  • Takes an active role and applies subject matter expertise in establishing phase-appropriate process development and manufacturing strategies,
  • Implements Quality by Design (QbD) and applies risk-based principles to drug product development programs, including technical & quality risk assessments, Design of Experiments, and identification of critical quality attributes, critical process parameters, and manufacturing control strategies.
  • Supports production deviation & event investigations.
  • Provide technical support for IND and BLA filings.
  • Assists in the responses to health authority questions.
  • Leads process optimization efforts for improving functional processes and technical operations within CMC.
  • Participates in technical audits during vendor selection.

Qualifications and Experience

  • BS/MS with at least fifteen (15) years of experience or a Ph.D. with at least ten (10) years of experience in a bio-pharmaceutical area with appropriate therapeutic product development experience.
  • Experience in the development of lipid based drugs is a plus.
  • Successful leadership of drug product development.
  • Excellent awareness & understanding of other stakeholder roles and drug product development's relationship to them.
  • Excellent working knowledge of CGMP, regulatory guidance, and compendial requirements, including FDA, EMA, ICH, WHO, USP-NF and EP.
  • Demonstrable experience as a primary author of CMC sections in regulatory filings, such as IND, IMPD, and NDA.
  • Excellent technical writing, oral, presentation, and interpersonal communication skills.
  • Excellent data presentation & analysis skills, including the creation of publication quality tables & graphs.
  • Fluent in the Microsoft ecosystem, including Office & SharePoint, and PDF publication & editing software such as Adobe Acrobat. Comfortable with electronic records & digital workflows.
  • Detail-oriented and organized.
  • Possesses high integrity and exceptional work ethic.
  • Must be flexible and able to multitask, prioritize, meet deadlines in a fast-paced environment, and be adaptable to setbacks. Exceptional problem-solving skills.
  • Team oriented; ability to work collaboratively with internal colleagues and vendors.
  • Understands and anticipates the impact of business and commercial needs on advanced-stage drug development.
  • Some travel required, including both domestic and international (10%).
(Sr.) Manager, Analytical Development

About Matinas BioPharma 

Matinas BioPharma is a clinical-stage biopharmaceutical company focused on developing next generation therapeutics to advance standards of care for patients in areas of significant unmet medical need. Company leadership has a deep history and knowledge of drug development and is supported by a world-class team of scientific advisors. 

In particular, Matinas is developing a portfolio of products based upon its proprietary lipid nanocrystal (LNC) drug delivery platform, which can solve complex challenges relating to the safe and effective delivery of potent medicines, making them orally bioavailable, less toxic and targeted to cells and tissues. 

About the position: 

This is a primarily hands-on lab position to provide critical analytical feedback to our lipid nanocrystal formulation team. The main responsibility is to support key analytical method development and characterization activities within the Discovery group. In this role, you will be responsible for developing fit-for-use analytical methods that will be used to assess and screen lipid nanocrystal formulations and stability.  Major activity involves HPLC method development to characterize drug encapsulation efficiency by separating and quantifying drugs that are distributed in aqueous phase, free crystal forms, and encapsulated in lipid nanocrystal. Other responsibility includes identification and quantification of lipid excipient and drug product stability studies. In addition to chromatography-based methods for the qualification/quantitation of lipids, proteins, nucleic acids, and drug, other techniques for nanoparticle biophysical characterization, such as particle size analysis, zeta potential, microscopy, etc., will be utilized as well.  

Based upon the versatility of our LNC technology platform, a wide range of drug substances will be investigated: small molecules, proteins/peptides, monoclonal antibodies, mRNA, DNA, oligonucleotides, etc.  Bioanalytical experience on quantification, stability evaluation, intracellular trafficking, and in vitro potency of such modalities will be a major plus.  

While you will be mostly developing non-GMP research fit-for-use analytical methods, you will serve as a liaison to transfer the method from discovery to GMP development team once method development completed.  GMP analytical experiences on method verification and validation are a major plus. 

Responsibility: 

  • Work very closely with formulation team to provide timely analytical feedback for lipid nanocrystal formulation development.  
  • Independently develop HPLC methods to characterize drug encapsulation efficiency and stability. 
  • Independently develop fit-for-use analytical methods to quantify lipids and assess lipid stability. 
  • Interact with external partners for tech transfer, evaluation, and optimization of their assays. 
  • Write and review assay protocols and prepare reports of experimental findings. 
  • Serve as an analytical liaison for method transferred out to GMP analytical team, or transferred in from external collaborators. 

Qualifications: 

  • Ph.D. in analytical chemistry or MS with an outstanding track record 
  • At least 3-5 years of HPLC method development and validation experiences in pharmaceutical industry 
  • Proficient with common analytical techniques and instrumentations:  separation techniques (e.g., HPLC, GC, TLC), in-vitro dissolution, general/wet chemical methods, physical characterizations (e.g., particle size analysis, SEM and light microscopy), spectroscopy (e.g., UV/Vis and FTIR) and thermal methods (e.g., DSC, TGA). 
  • Strong knowledge of industry practices and regulatory guidance for a variety of analytical development, qualification/ validation.  
  • Extensive hands-on experience with the design, development, optimization, qualification and validation technologies. 

 

Physical Qualifications 

Standing to perform bench tests, bending, lifting up to 40 lbs, and ability to wear all required safety equipment such as safety glasses, mask, gloves, lab coat as work and environment require. 

 

To apply please email your resume to Careers@MatinasBioPharma.com

(Sr.) Manager, Cell-based Assay Development

About Matinas BioPharma

Matinas BioPharma is a clinical-stage biopharmaceutical company focused on developing next generation therapeutics to advance standards of care for patients in areas of significant unmet medical need. Company leadership has a deep history and knowledge of drug development and is supported by a world-class team of scientific advisors.

In particular, Matinas is developing a portfolio of products based upon its proprietary lipid nanocrystal (LNC) drug delivery platform, which can solve complex challenges relating to the safe and effective delivery of potent medicines, making them orally bioavailable, less toxic and targeted to cells and tissues.

About the position:

The main responsibility for this role is to independently establish a cell culture lab, maintain a cell bank, develop and perform cell-based assays to provide critical feedback to guide LNC drug product development and formulation optimization. Based upon the versatility of our LNC technology platform, a wide range of drug substances will be investigated: small molecules, proteins/peptides, monoclonal antibodies, mRNA, DNA, oligonucleotides, etc. Quantification, stability evaluation, intracellular trafficking, and in vitro potency of such modalities will be the essential element of the role. The relevant assays may include intracellular uptaking assessments, gene expression, gene knock-down, RNA stability, cytotoxicity, and/or in vitro biological potency. This position will report to the CTO but operate with considerable autonomy under minimal supervision; therefore, the incumbent is expected to be a self-starter with at least 3-5 years bioanalytical and assay development experience with a proven track record.

Responsibility:

  • Establish a cell culture lab: acquire necessary instruments and materials to establish a cell culture lab and maintain a cell bank
  • Develop and optimize cell-based assays to evaluate lipid nanocrystal formulations, and provide critical feedback to formulation team
  • Interact with external partners for tech transfer, evaluation, and optimization of their assays
  • Write and review assay protocols and prepare reports of experimental findings
  • Report and document results in a timely fashion
  • Participate in the tech transfer of formulations developed to the GMP manufacturing and analytical labs, as appropriate

Qualifications:

  • Ph.D. in molecular biology, biochemistry, biomedical engineering, pharmaceutical science, or MS with an outstanding track record
  • 3-5 years of cell-based assay development and validation experiences in biopharmaceutical industry
  • 3-5 years of experience in establishing and operating a cell culture lab, and maintaining a cell bank
  • Assay development expertise with mRNA, SiRNA, DNA, oligonucleotides, proteins, etc.
  • Strong knowledge of industry practices and regulatory guidance for a variety of biological assay development, qualification/ validation
  • Extensive hands-on experience with the design, development, optimization, qualification and validation technologies (e.g., ELISA, MSD, flow cytometry and cell based-proliferation, fluorescence, antibody characterizations, reporter and cytotoxicity assays)
  • Proficiency in common software and data analysis packages (e.g., SoftMax Pro, GraphPad Prism, JMP, Microsoft Office tools).

Physical Qualifications

Standing to perform bench tests, bending, lifting up to 40 lbs, and ability to wear all required safety equipment such as safety glasses, mask, gloves, lab coat as work and environment require.

To apply please email your resume to Careers@MatinasBioPharma.com

(Sr.) Manager, Cell-based Assay Development

About Matinas BioPharma 

Matinas BioPharma is a clinical-stage biopharmaceutical company focused on developing next generation therapeutics to advance standards of care for patients in areas of significant unmet medical need. Company leadership has a deep history and knowledge of drug development and is supported by a world-class team of scientific advisors. 

In particular, Matinas is developing a portfolio of products based upon its proprietary lipid nanocrystal (LNC) drug delivery platform, which can solve complex challenges relating to the safe and effective delivery of potent medicines, making them orally bioavailable, less toxic and targeted to cells and tissues. 

About the position: 

The main responsibility for this role is to independently establish a cell culture lab, maintain a cell bank, develop and perform cell-based assays to provide critical feedback to guide LNC drug product development and formulation optimization.  Based upon the versatility of our LNC technology platform, a wide range of drug substances will be investigated: small molecules, proteins/peptides, monoclonal antibodies, mRNA, DNA, oligonucleotides, etc.  Quantification, stability evaluation, intracellular trafficking, and in vitro potency of such modalities will be the essential element of the role. The relevant assays may include intracellular uptaking assessments, gene expression, gene knock-down, RNA stability, cytotoxicity, and/or in vitro biological potency.  This position will report to the CTO but operate with considerable autonomy under minimal supervision; therefore, the incumbent is expected to be a self-starter with at least 3-5 years bioanalytical and assay development experience with a proven track record.  

 

Responsibility: 

  • Establish a cell culture lab: acquire necessary instruments and materials to establish a cell culture lab and maintain a cell bank 
  • Develop and optimize cell-based assays to evaluate lipid nanocrystal formulations, and provide critical feedback to formulation team 
  • Interact with external partners for tech transfer, evaluation, and optimization of their assays 
  • Write and review assay protocols and prepare reports of experimental findings 
  • Report and document results in a timely fashion 
  • Participate in the tech transfer of formulations developed to the GMP manufacturing and analytical labs, as appropriate 

Qualifications: 

  • Ph.D. in molecular biology, biochemistry, biomedical engineering, pharmaceutical science, or MS with an outstanding track record 
  • 3-5 years of cell-based assay development and validation experiences in biopharmaceutical industry 
  • 3-5 years of experience in establishing and operating a cell culture lab, and maintaining a cell bank 
  • Assay development expertise with mRNA, SiRNA, DNA, oligonucleotides, proteins, etc. 
  • Strong knowledge of industry practices and regulatory guidance for a variety of biological assay development, qualification/ validation  
  • Extensive hands-on experience with the design, development, optimization, qualification and validation technologies (e.g., ELISA, MSD, flow cytometry and cell based-proliferation, fluorescence, antibody characterizations, reporter and cytotoxicity assays) 
  • Proficiency in common software and data analysis packages (e.g., SoftMax Pro, GraphPad Prism, JMP, Microsoft Office tools). 

 

Physical Qualifications 

Standing to perform bench tests, bending, lifting up to 40 lbs, and ability to wear all required safety equipment such as safety glasses, mask, gloves, lab coat as work and environment require. 

 

To apply please email your resume to Careers@MatinasBioPharma.com 

(Sr.) Manager, Lipid Nanocrystal Formulation

About Matinas BioPharma

Matinas BioPharma is a clinical-stage biopharmaceutical company focused on developing next generation therapeutics to advance standards of care for patients in areas of significant unmet medical need. Company leadership has a deep history and knowledge of drug development and is supported by a world-class team of scientific advisors.

In particular, Matinas is developing a portfolio of products based upon its proprietary lipid nanocrystal (LNC) drug delivery platform, which can solve complex challenges relating to the safe and effective delivery of potent medicines, making them orally bioavailable, less toxic and targeted to cells and tissues.

About the position:

This is a hands-on lab position focusing on formulation, characterization, and process development of our proprietary LNC drug delivery system, which has proven applications to a variety of therapeutic areas and drug classes including infectious diseases, vaccines, mRNA, DNA, and/or oligonucleotide-based gene therapy, peptides/proteins, biologics, and small molecules. Formulation, process development, and optimization of these treatment modalities will be an essential element of the role. This position will report to CTO of the company.

Responsibilities:

  • Develop and optimize LNC delivery systems with formulation composition, excipients, process conditions
  • Understand the intricacy of LNC system, and propose new ideas/strategies to address deficiencies and optimize opportunities through innovative thinking
  • Characterize fundamental nanoparticulated properties: particle size, encochleation efficiency, stability, drug release, etc.
  • Drive internal and external projects to successful completion with high quality and precision in a timely fashion
  • Support ongoing process optimization and scale-up for existing clinical programs and new projects
  • Provide technical expertise to support tech transfer from Research to Development manufacturing and GMP analytical lab
  • Writing/reviewing formulation and analytical protocols and reports

Qualifications:

  • Ph.D. in chemistry, chemical engineering, biology, biochemistry, pharmaceutical science, or MS with an outstanding track record
  • 3-5 years of pharmaceutical formulation development experiences with a successful track record in formulation development and problem-solving
  • In-depth understanding and experience in lipid nanoparticle formulation, phospholipids, mRNA, SiRNA, proteins, etc.
  • Proficient in analytical techniques and nanoparticle characterizations: particle size, HPLC, DSC, RiboGreen assay, etc.
  • Experience in assay development, particularly cell-based assay, is a major plus
  • Experience in lyophilization, spray-drying, and fill-finish is a plus

Physical Qualifications

Standing to perform bench tests, bending, lifting up to 40 lbs, and ability to wear all required safety equipment such as safety glasses, mask, gloves, lab coat as work and environment require.

To apply please email your resume to Careers@MatinasBioPharma.com

(Sr.) Manager, Lipid Nanocrystal Formulation

About Matinas BioPharma 

Matinas BioPharma is a clinical-stage biopharmaceutical company focused on developing next generation therapeutics to advance standards of care for patients in areas of significant unmet medical need. Company leadership has a deep history and knowledge of drug development and is supported by a world-class team of scientific advisors. 

In particular, Matinas is developing a portfolio of products based upon its proprietary lipid nanocrystal (LNC) drug delivery platform, which can solve complex challenges relating to the safe and effective delivery of potent medicines, making them orally bioavailable, less toxic and targeted to cells and tissues. 

About the position: 

This is a hands-on lab position focusing on formulation, characterization, and process development of our proprietary LNC drug delivery system, which has proven applications to a variety of therapeutic areas and drug classes including infectious diseases, vaccines, mRNA, DNA, and/or oligonucleotide-based gene therapy, peptides/proteins, biologics, and small molecules.  Formulation, process development, and optimization of these treatment modalities will be an essential element of the role. This position will report to CTO of the company. 

Responsibilities: 

  • Develop and optimize LNC delivery systems with formulation composition, excipients, process conditions 
  • Understand the intricacy of LNC system, and propose new ideas/strategies to address deficiencies and optimize opportunities through innovative thinking 
  • Characterize fundamental nanoparticulated properties: particle size, encochleation efficiency, stability, drug release, etc. 
  • Drive internal and external projects to successful completion with high quality and precision in a timely fashion 
  • Support ongoing process optimization and scale-up for existing clinical programs and new projects 
  • Provide technical expertise to support tech transfer from Research to Development manufacturing and GMP analytical lab 
  • Writing/reviewing formulation and analytical protocols and reports 

Qualifications: 

  • Ph.D. in chemistry, chemical engineering, biology, biochemistry, pharmaceutical science, or MS with an outstanding track record 
  • 3-5 years of pharmaceutical formulation development experiences with a successful track record in formulation development and problem-solving 
  • In-depth understanding and experience in lipid nanoparticle formulation, phospholipids, mRNA, SiRNA, proteins, etc. 
  • Proficient in analytical techniques and nanoparticle characterizations: particle size, HPLC, DSC, RiboGreen assay, etc. 
  • Experience in assay development, particularly cell-based assay, is a major plus  
  • Experience in lyophilization, spray-drying, and fill-finish is a plus 

 

Physical Qualifications 

Standing to perform bench tests, bending, lifting up to 40 lbs, and ability to wear all required safety equipment such as safety glasses, mask, gloves, lab coat as work and environment require. 

 

To apply please email your resume to Careers@MatinasBioPharma.com 

Technician, Clinical Manufacturing

The Clinical Manufacturing Technician, LNC Manufacturing is responsible for the safe and compliant manufacture of clinical drug products as well as maintaining the manufacturing area in a clean, well supplied, and orderly state.

The Clinical Manufacturing Operator, LNC Manufacturing Will Be Specifically Responsible For

  • Manufacturing of Clinical Supply Batches
  • Packaging and Labeling of Clinical Supply Batches
  • Following area Standard Operating Procedures
  • Cleaning of the Clinical Manufacturing Facilities and Equipment.
  • Management of Inventory to include Raw Materials, API, and Finished Goods. Responsible for receipt, sampling, and inventory tracking.
  • Maintaining USP Purified Water system
  • Cleaning and Use Log Entries
  • Supporting the introduction of new products and technologies into the facility.
  • Maintaining the clinical batch manufacturing area in compliance with Regulatory Agency requirements.
  • Any other duties assigned.

Reports To

Manager, Clinical Manufacturing

Qualifications

High School diploma and 5-8 years of drug product manufacturing or operations experience OR

Associate degree and 3-5 years of drug product manufacturing or operations experience

To apply please email your resume to Careers@MatinasBioPharma.com