Annual report pursuant to Section 13 and 15(d)

Stock-based Compensation (Details Narrative)

v3.22.0.1
Stock-based Compensation (Details Narrative) - USD ($)
12 Months Ended
May 08, 2014
Dec. 31, 2021
Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based payment award increase of shares offering date January 1, 2015    
Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Outstanding Stock Maximum 4.00%   4.00%
Number of option vested   14,625,397  
Option vested price per share   $ 1.20  
Option intrinsic value   $ 2,500  
Aggregate intrinsic price   $ 1.01  
Unrecognized share-based compensation   $ 11,700,000  
Share-based compensation weighted average period   2 years 10 months 24 days  
Vesting description   All outstanding options expire ten years from date of grant. Options granted to employees prior to 2018 vest in equal monthly installments over three years. Beginning in 2018, options granted to employees vest over four years, with 25% of the shares vesting on the first annual anniversary of grant and the remaining shares vesting in 36 equal monthly installments over the following 3 years. A portion of options granted to consultants vests over four years, with the remaining vesting being based upon the achievement of certain performance milestones, which are tied to either financing or drug development initiatives  
Stock options expire term   10 years  
Number of restricted stock awards granted   31,769 379,385
General and administrative expense   $ 100,000 $ 292,000
Share-based Payment Arrangement, Option [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock option shares vesting percentage   25.00%  
2013 Equity Compensation Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Option granted description   granted at prices not less than 100% of the fair value of the shares  
Option term   The term of the options is no longer than ten years  
Number of common stock issued under plan   36,952,460  
2013 Equity Compensation Plan [Member] | Minimum [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Option vested period   3 years  
2013 Equity Compensation Plan [Member] | Maximum [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Option vested period   4 years