Annual report pursuant to Section 13 and 15(d)


Cover - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2021
Mar. 04, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K/A    
Amendment Flag true    
Amendment Description This Amendment No. 1 (the “Amendment”) to the Annual Report on Form 10-K of Matinas BioPharma Holdings Corp. (the “Company”) for the fiscal year ended December 31, 2021, originally filed with the Securities and Exchange Commission (the “SEC”) on March 8, 2022 (the “Original Filing”), is being filed solely to correct an administrative error in the content of Item 8, Financial Statements and Supplementary Data in the Original Filing (“Item 8”). Item 8 incorrectly identified EisnerAmper LLP’s PCAOB ID as 247. The correct PCAOB ID for EisnerAmper LLP is 274.    
Document Annual Report true    
Document Transition Report false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Period Focus FY    
Document Fiscal Year Focus 2021    
Current Fiscal Year End Date --12-31    
Entity File Number 001-38022    
Entity Central Index Key 0001582554    
Entity Tax Identification Number 46-3011414    
Entity Incorporation, State or Country Code DE    
Entity Address, Address Line One 1545 Route 206 South    
Entity Address, Address Line Two Suite 302    
Entity Address, City or Town Bedminster    
Entity Address, State or Province NJ    
Entity Address, Postal Zip Code 07921    
City Area Code 908    
Local Phone Number 484-8805    
Title of 12(b) Security Common Stock, par value $0.0001    
Trading Symbol MTNB    
Security Exchange Name NYSE    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity Shell Company false    
Entity Public Float     $ 160.0
Entity Common Stock, Shares Outstanding   216,864,526  
Auditor Firm ID 274    
Auditor Name EISNERAMPER LLP    
Auditor Location Iselin, New Jersey